Neonatal Neutropenia Due to Maternal Isoimmunization

Neonatal neutropenia due to maternal autoantibodies against neutrophils.

Familial Neonatal Neutropenia with Maternal Leukocyte Antibodies

I SOIMMUNE leukocyte antibodies have been reported frequently since the initial communication of Dausset and Nenna’ in 1952. A large literature has accumulated and was recently fully reviewed by Walford,2 who listed over 500 reports. Most of these have been concerned chiefly with establishing the presence of such antibodies, the mechanisms by which they cause pathological effects being still co...

Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia.

The healthy mother of a child with transient immune neutropenia was found to be "NA-null." The mother's neutrophils did not react with anti-NA1 and anti-NA2 antibodies (polyclonal human alloantibodies and mouse monoclonal antibodies). A healthy donor was discovered during routine neutrophil antigen typing whose neutrophils were also "NA-null." This NA-phenotype was due to the absence of FcRIII ...

Neonatal jaundice due to Rhesus and AB isoimmunization and frequency of these antigens in Pakistani mothers.

Frequency of Rhesus and ABO blood groups was determined in 3012 mothers. The blood groups in order of frequency were B, O, A and AB. Only 6.2% mothers were rhesus negative. ABO haemolytie disease of the newborn (HDN) accounted for 15.7% and Rh-HDN for 12.7% of 306 neonate admitted with Jaundice. No significant difference was found in two groups when levels of serum bilirubin, exchange transfusi...

Repeated severe neonatal hemolysis due to Rhesus isoimmunization in a pregnant woman.

Rhesus (Rh) isoimmunization presenting as severe neonatal hemolytic disease is rare in RhD negative primigravidas of Chinese ethnicity. We report the case of a 32-year-old pregnant Taiwanese woman, RhD negative, who gave birth vaginally to two RhD-positive full-term fetuses 6 years apart. Antenatal follow-up was uneventful and there was no obvious fetal-maternal hemorrhage except at the perform...